[1] HAUSER K F，KNAPP P E. Opiate drugs with abuse liability hijack the endogenous opioid system to disrupt neuronal and glial maturation in the central nervous system. Front Pediatr，2018，5：294.

[2] CONVERTINO M，SAMOSHKIN A，GAUTHIER J，et al. μ-opioid receptor 6-transmembrane isoform：A potential therapeutic target for new effective opioids. Prog Neuropsychopharmacol Biol Psychiatry，2015，62：61-67.

[3] UHARI-VÄÄNÄNEN J，RAASMAJA A，BÄCKSTRÖM P，et al. Accumbal μ-opioid receptors modulate ethanol intake in alcohol-preferring alko alcohol rats. Alcohol Clin Exp Res，2016，40：2114-2123.

[4] TAN K Z，CUNNINGHAM A M，JOSHI A，et al. Expression of kappa opioid receptors in developing rat brain - Implications for perinatal buprenorphine exposure. Reprod Toxicol，2018，78：81-89.

[5] AHONEN T J，RINNE M，GRUTSCHREIBER P，et al. Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors. Eur J Med Chem，2018，151：495-507.

[6] MURALI S S，NAPIER I A，RYCROFT B K，et al. Opioid-related（ORL1）receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels. J Physiol，2012，590：1655-1667.

[7] SUDAKOV S K，BASHKATOVA V G，KOLPAKOV A A，et al. Central and peripheral mu-opioid systems in the mechanisms of emotional stress. Vestn Ross Akad Med Nauk，2011，3：3-6.

[8] ZHANG X，BAO L，LI S. Opioid receptor trafficking and interaction in nociceptors. Br J Pharmacol，2015，172：364-374.

[9] BARDONI R，TAWFIK V L，WANG D，et al. Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn. Neuron，2014，81：1312-1327.

[10] COLLIER H O. Consequences of interaction between opioid and receptor. Biochem Soc Trans，1977，5：70-73.

[11] ZHOU H Y，CHEN S R，CHEN H，et al. Opioid-induced long-term potentiation in the spinal cord is a presynaptic event. J Neurosci，2010，30：4460-4466.

[12] HEINKE B，GINGL E，SANDKÜHLER J. Multiple targets of μ-opioid receptor-mediated presynaptic inhibition at primary afferent A _δ- and C- fibers. J Neurosci，2011，31：1313-1322.

[13] MIKA J，OBARA I，PRZEWLOCKA B. The role of nociceptin and dynorphin in chronic pain：implications of neuro-glial interaction. Neuropeptides，2011，45：247-261.

[14] SUN S，WANG J，BAO N，et al. Comparison of dexmedetomidine and fentanyl as local anesthetic adjuvants in spinal anesthesia：a systematic review and meta-analysis of randomized controlled trials. Drug Des Devel Ther，2017，11：3413-3424.

[15] TANG J S，QU C L，HUO F Q. The thalamic nucleus submedius and ventrolateral orbital cortex are involved in nociceptive modulation：a novel pain modulation pathway. Prog Neurobiol，2009，89：383-389.

[16] OSSIPOV M H，LAI J，KING T，et al. Antinociceptive and nociceptive actions of opioids. J Neurobiol，2004，61：126-148.

[17]徐建国．疼痛药物治疗学．北京：人民卫生出版社，2007：79-130.

[18] CHIDAMBARAN V，SADHASIVAM S，MAHMOUD M. Codeine and opioid metabolism：implications and alternatives for pediatric pain management. Curr Opin Anaesthesiol，2017，30（3）：349-356.

[19] ALI S，TAHIR B，JABEEN S，et al. Methadone treatment of opiate addiction：a systematic review of comparative studies. Innov Clin Neurosci，2017，14（7-8）：8-19.

[20] ALEXANDER-WILLIAMS J M，ROWBOTHAM D J. Novel routes of opioid administration. Br J Anaesth，1998，81（1）：3-7.

[21] BUDD K，SHIPTON E A. Codeine and opioid metabolism – implications and alternatives for pediatric pain management. Acute Pain，2004，6：123-135.

[22] GAMMAITONI A R，FINE P，ALVAREZ N，et al. Clinical application of opioid equianalgesic data. Clin J Pain，2003，19（5）：286-297.

[23] KALSO E，ALLAN L，DELLEMIJN P L，et al. Recommendations for using opioids in chronic non-cancer pain. Eur J Pain，2003，7（5）：381-386.

[24] SCHUG S A，SIDEBOTHAM D A，MCGUINNETY M，et al. Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain. Anesth Analg，1998，87（2）：368-372.

[25] SIMPSON K H. Opioids for persistent non-cancer pain：recommendations for clinical practice. Br J Anaesth，2004，92（3）：326-328.

[26] VOGELSANG J，HAYES S R. Butorphanol tartrate（stadol）：a review. J Post Anesth Nurs，1991，6（2）：129-135.

[27] KUBICA-CIELIŃSKA A，ZIELIŃSKA M. The use of nalbuphine in paediatric anaesthesia. Anaesthesiol Intensive Ther，2015，47（3）：252-256.

[28] SETHI S，SARKAR R，GARG V，et al. Pentazocine-induced ulcers revisited. Int J Dermatol，2016，55（1）：e49-51.